Description

Benzonitrile, 4-Chloro-5-Fluoro-2-Hydroxy- CAS NO 474825-99-5 is a high-purity, multi-functional aromatic intermediate characterized by its distinct benzonitrile core substituted with chloro, fluoro, and hydroxyl groups. This compound is engineered to provide exceptional synthetic versatility and precise reactivity for advanced chemical synthesis. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides and fungicides, leveraging the bioactivity of its halogenated phenolic structure.
• Liquid Crystal & OLED Materials: Used in the research and development of advanced electronic display materials due to its stable aromatic system and polarizable nitrile group.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, such as Suzuki and Buchwald-Hartwig amination, to introduce functionalized aryl groups.
• Coordination Chemistry Ligand: Acts as a ligand precursor for metal-organic frameworks (MOFs) and catalysts, where the nitrile and hydroxyl groups can coordinate to metal centers.
• Chemical Research & Development: A valuable standard and starting material in academic and industrial R&D labs for exploring new synthetic pathways.

Basic Information

Product Name	Benzonitrile, 4-Chloro-5-Fluoro-2-Hydroxy-
CAS No.	474825-99-5
Molecular Formula	C7H3ClFNO
Molecular Weight	171.56 g/mol
Synonyms	4-Chloro-5-fluoro-2-hydroxybenzonitrile; 2-Hydroxy-4-chloro-5-fluorobenzonitrile; 4-Chloro-5-fluorosalicylonitrile; 2-Cyano-4-chloro-5-fluorophenol; 5-Fluoro-4-chloro-2-hydroxybenzonitrile; 2-Hydroxy-4-chloro-5-fluorobenzene carbonitrile; 4-Chloro-5-fluoro-2-hydroxybenzenecarbonitrile
EINECS	Contact for details

Quality Control

Our Benzonitrile, 4-Chloro-5-Fluoro-2-Hydroxy- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request. We adhere to cGMP guidelines where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.