Description

4,4,5,5-Tetramethyl-2-(4-Trifluoromethoxyphenyl)-1,3,2-Dioxaborolane CAS NO 474709-28-9 is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound is a critical intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing trifluoromethoxy-substituted biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Material Science: Serves as a precursor for organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its stable boronate ester group.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for methodology development and creating complex molecular libraries via palladium-catalyzed cross-coupling.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands and organometallic catalysts.
• Fine Chemical Production: Integral to the multi-step synthesis of high-value, complex specialty chemicals.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(4-Trifluoromethoxyphenyl)-1,3,2-Dioxaborolane
CAS No.	474709-28-9
Molecular Formula	C₁₃H₁₆BF₃O₃
Molecular Weight	288.07 g/mol
Synonyms	2-(4-(Trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl trifluoromethyl ether; 4-(Trifluoromethoxy)phenylboronic acid pinacol ester; (4-Trifluoromethoxyphenyl)boronic acid pinacol ester; 4-Trifluoromethoxyphenylboronic acid pinacol ester; Pinacol (4-(trifluoromethoxy)phenyl)boronate; 4,4,5,5-Tetramethyl-2-[4-(trifluoromethoxy)phenyl]-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our production of 4,4,5,5-Tetramethyl-2-(4-Trifluoromethoxyphenyl)-1,3,2-Dioxaborolane adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) upon request, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.