Description

Bupivacaine-D9 is a deuterium-labeled analog of the widely used local anesthetic bupivacaine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS, by correcting for variations in sample preparation and instrument response. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical research sectors who require precise quantification of bupivacaine in complex biological matrices.

Application

• Internal Standard for Bioanalysis: Primary use as a quantitative internal standard in the LC-MS/MS analysis of bupivacaine in plasma, serum, and tissue samples.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic Toxicology: Supports the precise quantification of bupivacaine in post-mortem and human performance testing, crucial for legal and medical investigations.
• Pharmaceutical Quality Control: Used in the development and validation of analytical methods for drug product testing and impurity profiling.
• Reference Material for Method Development: Serves as a certified reference material for establishing and calibrating sensitive analytical assays.
• Clinical Research Monitoring: Facilitates therapeutic drug monitoring (TDM) to ensure patient safety and optimize dosing regimens during anesthesia.

Basic Information

Product Name	Bupivacaine-D9
CAS No.	474668-57-0
Molecular Formula	C18H19D9N2O
Molecular Weight	288.45 g/mol
Synonyms	1-Butyl-2',6'-pipecoloxylidide-d9; (RS)-1-Butyl-2',6'-pipecoloxylidide-d9; (±)-1-Butyl-2',6'-pipecoloxylidide-d9; DL-Bupivacaine-d9; Bupivacaine (phenyl-d9); Bupivacaine-d9 (deuterated, 9 deuterium atoms); Marcaine-d9; Sensorcaine-d9; 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, (phenyl-d9)-
EINECS	Contact for details

Quality Control

Our Bupivacaine-D9 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity (by HPLC), and residual solvent content. We support compliance with GLP (Good Laboratory Practice) and GMP (Good Manufacturing Practice) standards for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.