Description

2-((1S,4S)-4-(4-Chlorophenylsulfonyl)-4-(2,5-Difluorophenyl)Cyclohexyl)Acetonitrile is a high-purity, advanced pharmaceutical intermediate with a complex, stereochemically defined structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high selectivity and potency. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, especially for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel small-molecule drug candidates, particularly for CNS disorders.
• Preclinical Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Serves as a critical chiral intermediate for scaling up API synthesis under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development of complex organic molecules.
• Chemical Biology Probes: Potential use in the development of selective enzyme inhibitors or receptor modulators for research purposes.

Basic Information

Item	Details
Product Name	2-((1S,4S)-4-(4-Chlorophenylsulfonyl)-4-(2,5-Difluorophenyl)Cyclohexyl)Acetonitrile
CAS No.	471905-01-8
Molecular Formula	C20H18ClF2NO2S
Molecular Weight	409.88 g/mol
Synonyms	(1S,4S)-2-[4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]acetonitrile; 2-[(1S,4S)-4-(4-Chlorobenzenesulfonyl)-4-(2,5-difluorophenyl)cyclohexyl]acetonitrile; 471905-01-8; (1S,4S)-4-(4-Chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexylacetonitrile; CAS 471905-01-8
EINECS	Contact for details

Quality Control

Every batch of 2-((1S,4S)-4-(4-Chlorophenylsulfonyl)-4-(2,5-Difluorophenyl)Cyclohexyl)Acetonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting critical parameters such as chiral purity, chemical purity (HPLC), and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.