Description

Cevimeline n-Oxide is a key pharmaceutical intermediate and metabolite of the cholinergic agonist cevimeline. This compound matters for its critical role in advanced pharmaceutical research, development, and quality control processes. It is primarily needed by manufacturers and R&D laboratories in the pharmaceutical and biotechnology sectors for analytical reference standards, metabolic studies, and the synthesis of novel therapeutic agents.

Application

• Primary reference standard for the analytical quantification and identification of cevimeline and its metabolites in pharmaceutical formulations.
• Critical intermediate in the research-scale synthesis and process development of cholinergic agents and related compounds.
• Essential material for conducting in-vitro and in-vivo metabolic and pharmacokinetic studies.
• Used in quality control laboratories to develop and validate HPLC, LC-MS, and other analytical methods.
• Valuable reagent for pharmacological research targeting muscarinic acetylcholine receptors.
• Key starting material for the preparation of deuterated or other isotopically labeled analogs for use as internal standards.

Basic Information

Product Name	Cevimeline n-Oxide
CAS No.	469890-14-0
Molecular Formula	C10H17NO2S
Molecular Weight	215.31 g/mol
Synonyms	AF102B n-Oxide; Cevimeline N-Oxide; (2R,3R)-3-Methylspiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane] 1-Oxide; Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane] 1-Oxide, 3-Methyl-, (2R,3R)-; UNII-8T8Q1629VJ; 1-Azabicyclo[2.2.2]octane, 3-methylspiro[1,3-oxathiolane-5,3'-[3H]-, 1-oxide, (2'R,3'R)-
EINECS	Contact for details

Quality Control

Our Cevimeline n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.