Description

Norbuprenorphine Glucuronide is a key glucuronide metabolite of the opioid antagonist norbuprenorphine. This reference standard is critical for analytical and research applications requiring precise quantification and identification. It is primarily utilized by pharmaceutical R&D laboratories, forensic toxicology units, and clinical research organizations for method development, validation, and quality control in bioanalytical studies.

Application

• Pharmaceutical Reference Standard: For the calibration and validation of analytical methods (HPLC, LC-MS/MS) in drug metabolism and pharmacokinetic (DMPK) studies.
• Forensic Toxicology: Used as a certified reference material for the accurate identification and quantification of buprenorphine and its metabolites in biological samples.
• Clinical Research: Essential for studying the metabolic pathways, bioavailability, and excretion profiles of buprenorphine-based therapies.
• Bioanalytical Method Development: Serves as a critical component in developing robust assays for compliance testing and therapeutic drug monitoring.
• Quality Control Laboratories: Employed to ensure the accuracy and reliability of test results in pharmaceutical manufacturing and contract research organizations (CROs).

Basic Information

Product Name	Norbuprenorphine Glucuronide
CAS No.	469887-29-4
Molecular Formula	C33H45NO10
Molecular Weight	615.72 g/mol
Synonyms	Norbuprenorphine 3-β-D-Glucuronide; Nor-BUP Glucuronide; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6β-yl β-D-Glucopyranosiduronic Acid; 6β-Norbuprenorphine-3-β-D-Glucuronide; Buprenorphine Metabolite Glucuronide; Norbuprenorphine-3-Glucuronide
EINECS	Contact for details

Quality Control

Our Norbuprenorphine Glucuronide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for use as a reference standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines for reference materials to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.