Description

2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene is a high-value halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and a trifluoromethoxy substituent, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing advanced functional materials used in electronic displays and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine substituent acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl structures.
• Fluorine Chemistry Research: A valuable substrate for studying the influence of the trifluoromethoxy group on reaction kinetics, bioavailability, and lipophilicity in medicinal chemistry.
• Polymer Modification: Employed to introduce halogenated aromatic units into polymer backbones, altering thermal stability and chemical resistance.

Basic Information

Product Name	2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene
CAS No.	468075-00-5
Molecular Formula	C7H3BrClF3O
Molecular Weight	275.45 g/mol
Synonyms	1-Bromo-2-Chloro-4-(Trifluoromethoxy)Benzene; 2-Chloro-1-Bromo-4-(Trifluoromethoxy)Benzene; 4-Bromo-3-Chloro(Trifluoromethoxy)Benzene; Benzene, 2-bromo-1-chloro-4-(trifluoromethoxy)-; 2-Bromo-1-Chloro-4-(Trifluoromethoxy) Benzene; 3-Chloro-4-Bromo(Trifluoromethoxy)Benzene; 2-Bromo-1-Chloro-4-(Trifluoromethyloxy)Benzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-Chloro-4-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.