Description

Boc-3-Methyl-L-β-Phenylalanine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis. This compound is a critical chiral building block, enabling the precise introduction of a sterically hindered, methyl-substituted phenylalanine moiety into complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds where structural modification is key to optimizing activity and stability.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a modified phenylalanine residue with enhanced steric and electronic properties.
• Proteomics Research: Employed in the study of protein structure-function relationships and the design of enzyme inhibitors or receptor agonists/antagonists.
• Bioconjugation: Acts as a specialized linker or building block for creating peptide-drug conjugates or labeled peptides for diagnostic applications.
• Chemical Biology Tool: Utilized to probe biological systems and develop peptide libraries for high-throughput screening against various biological targets.
• Academic & Industrial R&D: Fundamental research reagent in universities and corporate labs for exploring new synthetic methodologies and bioactive molecule design.

Basic Information

Product Name	Boc-3-Methyl-L-β-Phenylalanine
CAS No.	464930-76-5
Molecular Formula	C15H21NO4
Molecular Weight	279.33 g/mol
Synonyms	(2S)-3-(3-Methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; N-(tert-Butoxycarbonyl)-3-methyl-L-β-phenylalanine; Boc-3-Me-L-β-Phe-OH; Boc-3-methyl-β-homo-phenylalanine; tert-Butyloxycarbonyl-3-methyl-L-β-phenylalanine; N-Boc-3-methyl-L-β-homophenylalanine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(m-tolyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Boc-3-Methyl-L-β-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and spectroscopic methods for structural confirmation. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.