Description

Galanthamine β-D-Glucuronide CAS NO 464189-56-8 is a high-purity, chemically defined reference standard and pharmaceutical intermediate. This compound is critical for analytical research and development, particularly in the synthesis and quality control of galantamine-based active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in the development of treatments for neurodegenerative conditions.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and impurity profiling of galantamine and its metabolites in HPLC, LC-MS, and other analytical methods.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic precursor in the production of galantamine hydrobromide and related drug substances.
• Metabolite Research: Essential for studying the pharmacokinetics, pharmacodynamics, and metabolic pathways of galantamine in preclinical and clinical research.
• Quality Control & Assurance: Employed in in-house QC laboratories to validate analytical methods and ensure batch-to-batch consistency of final drug products.
• Regulatory Compliance & Documentation: Supports regulatory filings (e.g., with FDA, EMA) by providing a characterized standard for method validation and specification setting.

Basic Information

Product Name	Galanthamine β-D-Glucuronide
CAS No.	464189-56-8
Molecular Formula	C23H29NO9
Molecular Weight	463.48 g/mol
Synonyms	Galanthamine β-D-Glucuronide; Galantamine β-D-Glucuronide; Galantamine Glucuronide; (4aS,6R,8aS)-5,6,9,10,11,12-Hexahydro-3-methoxy-11-methyl-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-yl β-D-Glucopyranosiduronic Acid; Galantamine Metabolite Standard; Nivalin Glucuronide
EINECS	Contact for details

Quality Control

Our Galanthamine β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical reference materials. Certificates of Analysis (COA) with detailed chromatographic data are provided for every lot to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.