Description

2-Cyano-5-Fluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical protected boronic acid building block, enabling efficient cross-coupling reactions for the construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides requiring fluorinated and cyano-substituted aromatic systems.
• Ligand & Catalyst Development: Serves as a building block for creating novel ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science: Employed in the synthesis of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Chemical Biology & Probe Synthesis: Useful for labeling and modifying biomolecules or creating fluorescent probes and imaging agents.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Cyano-5-Fluorophenylboronic Acid Pinacol Ester
CAS No.	463335-96-8
Molecular Formula	C₁₃H₁₅BFNO₂
Molecular Weight	247.08 g/mol
Synonyms	5-Fluoro-2-cyanophenylboronic acid pinacol ester; (5-Fluoro-2-cyanophenyl)boronic acid pinacol ester; 2-Cyano-5-fluorobenzeneboronic acid pinacol ester; 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 463335-96-8; Pinacol (5-fluoro-2-cyanophenyl)boronate; Benzonitrile, 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Each batch is characterized by NMR (1H, 13C, 19F, 11B), HPLC, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all analytical results are available upon request. We adhere to a quality management system to ensure batch-to-batch consistency and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations to prevent hydrolysis of the boronic ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.