Description

2-Cyano-4-Fluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical building block in modern organic synthesis, particularly in metal-catalyzed cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the fluorine and cyano substituents for bioactivity.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Chemical Biology Probes: Useful for constructing molecular probes and tags for studying biological processes, given its functional handle for further conjugation.
• Custom Synthesis & Contract Manufacturing: A vital raw material for custom synthesis organizations (CSOs) and CDMOs (Contract Development and Manufacturing Organizations) serving global R&D pipelines.

Basic Information

Product Name	2-Cyano-4-Fluorophenylboronic Acid Pinacol Ester
CAS No.	461451-63-8
Molecular Formula	C₁₃H₁₅BFNO₂
Molecular Weight	247.08 g/mol
Synonyms	4-Fluoro-2-cyanophenylboronic acid pinacol ester; 2-Cyano-4-fluorobenzeneboronic acid pinacol ester; (2-Cyano-4-fluorophenyl)boronic acid pinacol ester; 4-Fluoro-2-cyanobenzene-1-boronic acid pinacol ester; Pinacol (2-cyano-4-fluorophenyl)boronate; 2-(4-Fluoro-2-cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 461451-63-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2-Cyano-4-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including research and cGMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.