Description

n-[4-[(Trifluoroacetyl)Amino]Benzoyl-D4]-L-Glutamic Acid Dimethyl Ester is a high-purity, deuterated chemical intermediate designed for advanced research and development. This compound is critical for applications requiring isotopically labeled materials, offering enhanced stability and traceability in analytical studies. It is primarily utilized by pharmaceutical researchers, analytical chemists, and manufacturers of diagnostic reagents who require precise and reliable building blocks for synthesis and method development.

Application

• Pharmaceutical Research & Development: Serves as a key deuterated intermediate in the synthesis of novel drug candidates and metabolites for pharmacokinetic and metabolic stability studies.
• Analytical Chemistry & Mass Spectrometry: Used as an internal standard or reference material in LC-MS/MS and GC-MS analyses to ensure accurate quantification and method validation.
• Isotope Labeling: Essential for creating isotopically labeled compounds used in tracer studies, metabolic pathway analysis, and proteomics research.
• Diagnostic Reagent Manufacturing: Employed in the production of high-sensitivity diagnostic assays and kits that rely on stable isotope-labeled conjugates.
• Chemical Synthesis: Acts as a specialized building block for the preparation of more complex molecules containing trifluoroacetyl and glutamic acid ester functionalities.

Basic Information

Product Name	n-[4-[(Trifluoroacetyl)Amino]Benzoyl-D4]-L-Glutamic Acid Dimethyl Ester
CAS No.	461426-33-5
Molecular Formula	C₁₆H₁₂D₄F₃N₂O₆
Molecular Weight	401.33 g/mol
Synonyms	L-Glutamic acid, N-[4-[(trifluoroacetyl)amino]benzoyl-D4]-, dimethyl ester; Deuterated Trifluoroacetyl-Aminobenzoyl Glutamate Dimethyl Ester; (2S)-2-[(4-[(2,2,2-Trifluoroacetyl)amino]benzoyl-D4)amino]pentanedioic acid dimethyl ester; N-(4-((Trifluoroacetyl)amino)benzoyl-d4)-L-glutamic acid dimethyl ester; TFAGlu(OMe)2-d4; Isotope Labeled Glutamic Acid Ester Intermediate
EINECS	Contact for details

Quality Control

Our n-[4-[(Trifluoroacetyl)Amino]Benzoyl-D4]-L-Glutamic Acid Dimethyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹⁹F), HPLC, and mass spectrometry, to confirm chemical identity, isotopic enrichment (D4), and purity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.