Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(5-Methyl-1H-Indol-3-Yl)Propanoic Acid is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound, with CAS number 460751-68-2, serves as a critical building block for constructing complex peptide sequences with high fidelity and minimal side reactions. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the sequential assembly of peptides on resin, particularly those requiring the incorporation of tryptophan analogs.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs targeting GPCRs, enzymes, and protein-protein interactions.
• Bioconjugation: Acts as a precursor for creating peptide tags, linkers, or functionalized amino acids for antibody-drug conjugates (ADCs) or protein labeling.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive peptide leads.
• Biochemical Probe Development: Incorporated into peptides used as substrates, inhibitors, or activity-based probes for studying enzyme function.
• Academic & Institutional Research: Fundamental research tool for studying protein folding, structure-activity relationships (SAR), and peptide mimetics.

Basic Information

Item	Details
Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(5-Methyl-1H-Indol-3-Yl)Propanoic Acid
CAS No.	460751-68-2
Molecular Formula	C28H24N2O4
Molecular Weight	452.50 g/mol
Synonyms	Fmoc-5-methyl-Trp-OH; Fmoc-5-methyltryptophan; Fmoc-5-Me-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-methyl-L-tryptophan; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-methyl-1H-indol-3-yl)propanoic acid; 5-Methyl-L-tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-L-5-methyltryptophan; Fmoc-5-methyl-L-Trp
EINECS	Contact for details

Quality Control

Our (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(5-Methyl-1H-Indol-3-Yl)Propanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards expected for fine chemical and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.