Description

[(E)-2-(4-Fluorophenyl)Ethenyl]Boronic Acid is a high-value organoboron building block characterized by its trans-configured styryl boronic acid structure and a fluorine substituent. This compound is essential for modern synthetic chemistry, enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel fluorinated compounds and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated biaryl and styryl scaffolds in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of novel fluorinated pesticides and herbicides, where the fluorine atom can enhance biological activity and stability.
• Material Science Research: Serves as a precursor for synthesizing fluorinated organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The quintessential reagent for palladium-catalyzed Suzuki-Miyaura couplings with various organic halides, enabling efficient library synthesis.
• Fluorine Chemistry Studies: An important building block for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in organic molecules.
• Chemical Biology Probes: Can be utilized to create fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	[(E)-2-(4-Fluorophenyl)Ethenyl]Boronic Acid
CAS No.	460748-43-0
Molecular Formula	C8H8BFO2
Molecular Weight	165.96 g/mol
Synonyms	(E)-2-(4-Fluorostyryl)boronic acid; trans-2-(4-Fluorostyryl)boronic Acid; (E)-4-Fluorostyrylboronic Acid; (E)-2-(4-Fluorophenyl)vinylboronic Acid; 4-Fluoro-trans-styrylboronic Acid; (E)-1-(4-Fluorophenyl)ethene-1,2-diyl]diboronic Acid (tautomer); Boronic acid, B-[(1E)-2-(4-fluorophenyl)ethenyl]-; (E)-β-(4-Fluorophenyl)vinylboronic Acid
EINECS	Contact for details

Quality Control

Our [(E)-2-(4-Fluorophenyl)Ethenyl]Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.