Description

Cyclobutene, 1-Cyclopropyl-2,3,3-Trifluoro- (9Ci) is a specialized fluorinated cyclobutene derivative, identified by CAS NO 460744-88-1. This compound serves as a valuable and versatile advanced pharmaceutical intermediate and key building block in organic synthesis, prized for its unique cyclopropyl and trifluoro-substituted structure. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical sectors for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used as a building block for developing new-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Material Science Research: Employed in the development of specialty polymers and advanced materials, where its rigid cyclic structure can impart unique thermal and chemical resistance properties.
• Fluorine Chemistry & Catalysis: Serves as a model substrate or ligand precursor in organometallic chemistry and catalytic reaction studies, exploring C-F bond activation and functionalization.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies engaged in custom synthesis and scale-up projects for clients in life sciences.

Basic Information

Product Name	Cyclobutene, 1-Cyclopropyl-2,3,3-Trifluoro- (9Ci)
CAS No.	460744-88-1
Molecular Formula	C7H7F3
Molecular Weight	148.13 g/mol
Synonyms	1-Cyclopropyl-2,3,3-trifluorocyclobutene; 2,3,3-Trifluoro-1-cyclopropylcyclobutene; 1-Cyclopropyl-2,3,3-trifluoro-1-cyclobutene; 460744-88-1; Cyclobutene, 1-cyclopropyl-2,3,3-trifluoro-; Trifluorocyclopropylcyclobutene
EINECS	Contact for details

Quality Control

Our high-purity Cyclobutene derivative is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and MS, to ensure it meets exacting customer specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere to prevent degradation. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.