Description

5-Formyl-2-(trifluoromethoxy)benzeneboronic acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, combining a formyl group and a trifluoromethoxy substituent on the boronic acid-bearing aromatic ring, makes it an exceptionally versatile reagent for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and as a precursor for more elaborate functional groups.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially those requiring the trifluoromethoxy pharmacophore.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the boronic acid functionality enables efficient carbon-carbon bond formation.
• Material Science Research: Serves as a monomer or linker in the synthesis of organic electronic materials, metal-organic frameworks (MOFs), and functional polymers.
• Chemical Biology & Proteomics: Utilized as a handle for bioconjugation and in the synthesis of activity-based probes and inhibitors targeting serine hydrolases.
• Ligand Synthesis: Acts as a starting material for creating sophisticated bidentate and tridentate ligands used in catalysis.
• Fluorinated Compound Libraries: Essential for medicinal chemistry programs focused on building diverse screening libraries containing the metabolically stable trifluoromethoxy group.

Basic Information

Product Name	5-Formyl-2-(trifluoromethoxy)benzeneboronic Acid
CAS No.	459810-97-0
Molecular Formula	C8H6BF3O4
Molecular Weight	233.94 g/mol
Synonyms	[2-(Trifluoromethoxy)-5-formylphenyl]boronic acid; (5-Formyl-2-(trifluoromethoxy)phenyl)boronic acid; 2-(Trifluoromethoxy)-5-formylbenzeneboronic acid; 5-Carboxy-2-(trifluoromethoxy)benzeneboronic acid (precursor form); Boronic acid, B-[2-(trifluoromethoxy)-5-formylphenyl]-; CAS 459810-97-0
EINECS	Contact for details

Quality Control

Every batch of 5-Formyl-2-(trifluoromethoxy)benzeneboronic acid is manufactured and analyzed under strict quality management protocols to ensure consistency and purity for sensitive synthetic applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.