Description

1-((3R,4S,5R)-5-(2-(Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Ethyl)-4-Hydroxytetrahydrofuran-3-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is a sophisticated nucleoside derivative and a key protected intermediate in the synthesis of modified oligonucleotides. This compound is critical for researchers and manufacturers developing advanced therapeutic nucleic acids, such as antisense oligonucleotides and siRNA, where precise chemical modification is required for stability and efficacy. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and fine chemical suppliers specializing in the production of high-value active pharmaceutical ingredients (APIs) and nucleotide building blocks.

Application

• Oligonucleotide Synthesis: Serves as a crucial phosphoramidite precursor for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides designed for targeted gene silencing.
• siRNA and miRNA Therapeutics: Acts as a building block to incorporate specific modifications that enhance the nuclease resistance and pharmacokinetic profile of RNA-based therapeutics.
• Pharmaceutical Intermediates: A high-purity intermediate in the multi-step synthesis of complex nucleoside-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in academic and industrial labs for studying nucleic acid structure, function, and for developing novel diagnostic probes.
• Process Development & Scale-Up: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for process optimization and commercial-scale GMP manufacturing.

Basic Information

Product Name	1-((3R,4S,5R)-5-(2-(Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Ethyl)-4-Hydroxytetrahydrofuran-3-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione
CAS No.	458541-41-8
Molecular Formula	C32H34N2O7
Molecular Weight	558.62 g/mol
Synonyms	5-Methyl-dU-CE Phosphoramidite (DMT protected); 5-Methyl-2'-deoxyuridine, 5'-O-(4,4'-dimethoxytrityl)-; 5-Methyldeoxyuridine DMT; 1-[(2R,3S,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-hydroxyoxolan-2-yl]-5-methyl-pyrimidine-2,4-dione; Protected 5-Methyldeoxyuridine; Nucleoside Intermediate for Oligo Synthesis; DMT-5-Me-dU
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and reliability for critical research and GMP manufacturing. Identity and purity are confirmed through a battery of analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with each shipment. We support development from milligram to kilogram scale with documentation suitable for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Optical Rotation	Specific range provided per batch
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.