Description

2-Fluoropyridine-4-Boronic Acid Pinacol Ester is a high-value organoboron building block essential for modern synthetic chemistry. This compound is a key reagent in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing fluorinated pyridine derivatives with potential biological activity.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides containing fluorinated heterocyclic cores.
• Material Science: Serves as a precursor for creating functionalized ligands, organic semiconductors, and liquid crystal materials.
• Suzuki-Miyaura Cross-Coupling: The pinacol ester group protects the boronic acid, enhancing stability and handling for palladium-catalyzed C-C bond formation.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on medicinal chemistry and novel synthetic methodologies.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	2-Fluoropyridine-4-Boronic Acid Pinacol Ester
CAS No.	458532-86-0
Molecular Formula	C11H15BFNO2
Molecular Weight	223.05 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoropyridine; 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Fluoro-4-pyridineboronic acid pinacol ester; 2-Fluoro-4-(pinacolboryl)pyridine; 2-Fluoropyridin-4-ylboronic acid pinacol ester; 4-Borono-2-fluoropyridine pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Fluoropyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality system is designed to meet the stringent requirements of research and development, supporting your critical synthesis work with reliable, high-performance materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.