Description

3-Chloro- D-Phenylalanine, Methyl Ester, Hydrochloride is a chiral, non-natural amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a critical building block for the development of novel pharmaceuticals and bioactive molecules, particularly in the fields of peptide mimetics and enzyme inhibitors. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential therapeutic agents, including protease inhibitors and receptor antagonists.
• Peptidomimetics Research: Used to incorporate modified phenylalanine residues into peptide backbones to enhance stability, bioavailability, and biological activity.
• Chemical Biology Probes: Serves as a precursor for labeled compounds or activity-based probes used in mechanistic studies and target identification.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in stereoselective reactions to construct complex molecular architectures.
• Reference Standard: Used in analytical laboratories for method development and quality control of related pharmaceutical substances.

Basic Information

Product Name	3-Chloro- D-Phenylalanine, Methyl Ester, Hydrochloride
CAS No.	457654-75-0
Molecular Formula	C10H13Cl2NO2
Molecular Weight	250.12 g/mol
Synonyms	D-3-Chlorophenylalanine methyl ester hydrochloride; Methyl (R)-2-amino-3-(3-chlorophenyl)propanoate hydrochloride; (R)-Methyl 2-amino-3-(3-chlorophenyl)propanoate hydrochloride; (R)-Methyl 3-(3-chlorophenyl)-2-aminopropanoate hydrochloride; 3-Chloro-D-Phe-OMe·HCl; D-3-Cl-Phe-OMe·HCl
EINECS	Contact for details

Quality Control

Our 3-Chloro- D-Phenylalanine, Methyl Ester, Hydrochloride is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.