Description

Ac-Dl-Phe(4-F)-Oet is a fluorinated, acetylated phenylalanine ethyl ester derivative, serving as a key protected amino acid building block. This compound is essential for advanced peptide synthesis and medicinal chemistry research, offering a versatile scaffold for introducing structural and electronic modifications. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on developing novel therapeutic peptides and bioactive molecules.

Application

• Peptide Synthesis: A crucial protected intermediate for the solid-phase and solution-phase synthesis of complex peptides containing fluorinated phenylalanine residues.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the effects of fluorine substitution on peptide stability, bioavailability, and receptor binding affinity.
• Bioconjugation & Probe Development: Acts as a precursor for creating fluorescent or affinity-labeled peptide probes for biochemical and diagnostic applications.
• Pharmaceutical Intermediate: Serves as a building block in the development of potential active pharmaceutical ingredients (APIs) targeting metabolic disorders and neurological conditions.
• Academic & Industrial R&D: Employed in fundamental research exploring novel amino acid analogs and their incorporation into engineered proteins and biomaterials.

Basic Information

Product Name	Ac-Dl-Phe(4-F)-Oet
CAS No.	457654-53-4
Molecular Formula	C₁₃H₁₆FNO₃
Molecular Weight	253.27 g/mol
Synonyms	N-Acetyl-4-fluoro-DL-phenylalanine ethyl ester; Ethyl N-acetyl-4-fluoro-DL-phenylalaninate; Acetyl-4-fluoro-DL-phenylalanine ethyl ester; N-Acetyl-4-fluorophenylalanine ethyl ester; Ac-DL-Phe(4-F)-OEt; N-Acetyl-DL-4-fluorophenylalanine ethyl ester; DL-4-Fluoro-N-acetylphenylalanine ethyl ester
EINECS	Contact for details

Quality Control

Our Ac-Dl-Phe(4-F)-Oet is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed specifications for traceability and quality assurance, supporting compliance with cGMP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a desiccated environment to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.