Description

1,4-Difluoro-2-(Prop-2-Ynyloxy)Benzene is a high-purity fluorinated aromatic building block featuring a reactive alkyne functional group. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in click chemistry and cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of new drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other biologically active molecules.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides that require fluorinated aromatic structures for enhanced efficacy and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and advanced organic frameworks (MOFs/COFs).
• Click Chemistry Reagent: The propynyloxy group makes it an ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of bioconjugation and polymer functionalization.
• Organic Electronic Materials: Investigated as a building block for electron-transport materials, organic light-emitting diodes (OLEDs), and semiconductors due to its fluorinated aromatic core.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring novel synthetic pathways and creating complex molecular architectures.

Basic Information

Product Name	1,4-Difluoro-2-(Prop-2-Ynyloxy)Benzene
CAS No.	457628-36-3
Molecular Formula	C9H6F2O
Molecular Weight	168.14 g/mol
Synonyms	2-(Prop-2-yn-1-yloxy)-1,4-difluorobenzene; 1,4-Difluoro-2-(2-propynyloxy)benzene; Benzene, 1,4-difluoro-2-(2-propynyloxy)-; 1,4-Difluoro-2-(prop-2-yn-1-yloxy)benzene; 2-(Propagyloxy)-1,4-difluorobenzene; 1,4-Difluoro-2-prop-2-ynyloxybenzene; Difluoropropynyloxybenzene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including GC, HPLC, NMR, and MS to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request. Our quality management system supports the needs of research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.