Description

n-Boc-1-Bromo-2-Naphthalenamine is a protected aromatic amine derivative, serving as a versatile and high-value synthetic intermediate. Its core value lies in providing a reactive bromine handle and a protected amine group, enabling precise and sequential functionalization in complex molecule assembly. This compound is essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors, particularly for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and functional organic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in the development of naphthalene-based therapeutic agents.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides where the naphthalene scaffold imparts specific biological activity.
• Material Science Research: Serves as a precursor for organic semiconductors, liquid crystals, and photoactive materials due to its conjugated aromatic system.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Heck, and Buchwald-Hartwig amination reactions to form complex biaryl structures.
• Peptidomimetics & PROTACs: The Boc-protected amine is crucial for introducing naphthylamine motifs into peptide backbones or as linkers in proteolysis-targeting chimeras (PROTACs).
• Dye & Pigment Chemistry: Acts as an intermediate in the production of specialized naphthalene-based dyes and colorants.

Basic Information

Product Name	n-Boc-1-Bromo-2-Naphthalenamine
CAS No.	454713-47-4
Molecular Formula	C₁₅H₁₆BrNO₂
Molecular Weight	322.20 g/mol
Synonyms	1-Bromo-2-[(tert-butoxycarbonyl)amino]naphthalene; tert-Butyl (1-bromonaphthalen-2-yl)carbamate; N-Boc-2-Amino-1-bromonaphthalene; 2-Amino-1-bromonaphthalene N-Boc derivative; (1-Bromo-2-naphthyl)carbamic acid tert-butyl ester; Boc-1-Br-2-NH-Naphthalene; N-(tert-Butoxycarbonyl)-1-bromo-2-naphthalenamine
EINECS	Contact for details

Quality Control

Our n-Boc-1-Bromo-2-Naphthalenamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.