Description

Fmoc-Pro-Pro-Pro-Pro-Oh is a specialized, high-purity tetrapeptide building block protected with a fluorenylmethyloxycarbonyl (Fmoc) group at the N-terminus. This compound is essential for solid-phase peptide synthesis (SPPS), providing researchers and manufacturers with a reliable, sequence-specific reagent for constructing complex peptide chains. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic laboratories engaged in the development of peptide-based therapeutics, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical building block for the Fmoc-strategy synthesis of custom peptides containing proline-rich sequences.
• Pharmaceutical Research: Used in the discovery and development of novel peptide drugs targeting various diseases.
• Bioconjugation & Probe Development: Serves as a key intermediate for creating labeled peptides used in imaging, diagnostics, and target identification.
• Biochemical Studies: Employed to investigate protein-protein interactions, enzyme specificity, and structural biology where proline motifs are significant.
• Material Science: Potential use in the synthesis of peptide-based biomaterials and hydrogels with specific mechanical properties.

Basic Information

Product Name	Fmoc-Pro-Pro-Pro-Pro-Oh
CAS No.	454693-96-0
Molecular Formula	C44H50N4O9
Molecular Weight	778.90 g/mol
Synonyms	Fmoc-Pro-Pro-Pro-Pro-OH; Fmoc-Pro4-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-prolyl-L-prolyl-L-proline; Fmoc-L-Pro-L-Pro-L-Pro-L-Pro-OH; Fmoc-Pro-Pro-Pro-Pro; Fmoc-P4-OH; Tetrapeptide Fmoc-Pro4; N-α-Fmoc-L-prolyl-L-prolyl-L-prolyl-L-proline
EINECS	Contact for details

Quality Control

Our Fmoc-Pro-Pro-Pro-Pro-Oh is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, ensuring traceability and documentation for regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be kept under dry, inert conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Assay	≥ 97.0% (by HPLC)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.