Description

2,3,4,5,6-Pentafluorophenyl 1-Ethylenesulfonate is a specialized fluorinated sulfonate ester, a high-value building block in advanced organic synthesis. This compound matters for its unique reactivity, serving as a versatile electrophile for introducing the pentafluorophenylsulfonyl (Pfp-SO2) group, a valuable handle in medicinal chemistry and materials science. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules, particularly in the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in creating novel sulfonyl-containing herbicides, fungicides, and plant growth regulators.
• Peptide Chemistry: Acts as a sulfonylation reagent for modifying amino acid side chains or creating sulfonamide linkers in peptide mimetics.
• Polymer & Materials Science: Employed to introduce fluorinated sulfonate functionalities into polymers to alter solubility, thermal stability, or surface properties.
• Chemical Biology Probes: Useful for labeling biomolecules or creating activity-based probes due to the reactivity of the sulfonate ester group.
• Cross-Coupling Reactions: Serves as an electrophilic partner in palladium-catalyzed cross-coupling reactions to form carbon-sulfur bonds.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenyl 1-Ethylenesulfonate
CAS No.	452905-58-7
Molecular Formula	C8H3F5O3S
Molecular Weight	274.16 g/mol
Synonyms	Ethenesulfonic Acid 2,3,4,5,6-Pentafluorophenyl Ester; Pentafluorophenyl Ethenesulfonate; 2,3,4,5,6-Pentafluorophenyl Vinylsulfonate; Pfp Vinylsulfonate; Pentafluorophenyl Vinyl Sulfonate; Vinyl Pentafluorobenzenesulfonate; 452905-58-7
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorophenyl 1-Ethylenesulfonate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.