Description

1H-Pyrrole-3-Carbonyl Fluoride, 4-(Difluoromethyl)-1-Methyl- (9Ci) is a specialized fluorinated pyrrole derivative, a high-value building block in advanced organic synthesis. Its core value lies in the reactive carbonyl fluoride and difluoromethyl groups, which enable precise molecular modifications critical for developing novel compounds. This intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, especially in medicinal chemistry programs targeting enzyme inhibition or receptor modulation.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides and herbicides, where the fluorinated moiety can enhance biological activity and stability.
• Material Science Research: Serves as a precursor for creating functional polymers or advanced organic electronic materials with specific fluorinated architectures.
• Fluorination Chemistry: Acts as a versatile reagent for introducing fluorinated carbonyl groups into complex molecular scaffolds under controlled conditions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	1H-Pyrrole-3-Carbonyl Fluoride, 4-(Difluoromethyl)-1-Methyl- (9Ci)
CAS No.	448236-05-3
Molecular Formula	C7H6F3NO
Molecular Weight	177.12 g/mol
Synonyms	4-(Difluoromethyl)-1-methyl-1H-pyrrole-3-carbonyl fluoride; 1-Methyl-4-(difluoromethyl)-1H-pyrrole-3-carbonyl fluoride; 448236-05-3; 4-(Difluoromethyl)-1-methyl-pyrrole-3-carbonyl fluoride; 1-Methyl-4-difluoromethylpyrrole-3-carbonyl fluoride; 1H-Pyrrole-3-carbonyl fluoride, 4-(difluoromethyl)-1-methyl-
EINECS	Contact for details

Quality Control

Our 1H-Pyrrole-3-Carbonyl Fluoride, 4-(Difluoromethyl)-1-Methyl- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Isolate from strong alkalis and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid or clear to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical range 95-98%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.