Description

Boc-6-Methyl-Dl-Tryptophan is a protected derivative of the non-proteinogenic amino acid 6-methyltryptophan, featuring a tert-butoxycarbonyl (Boc) group on the amine functionality. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering enhanced stability and controlled reactivity during solid-phase and solution-phase coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, drug discovery, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new therapeutic agents, including enzyme inhibitors and receptor modulators.
• Peptide Synthesis: Used as a protected amino acid precursor in both solid-phase peptide synthesis (SPPS) and solution-phase methodologies to incorporate modified tryptophan residues.
• Medicinal Chemistry Research: Enables the study of structure-activity relationships (SAR) by introducing a methyl-substituted indole moiety into target molecules.
• Bioconjugation & Probe Development: Acts as a starting material for creating fluorescent probes, affinity labels, or other bioconjugates for biochemical assays.
• Academic & Industrial R&D: Employed in university and corporate laboratories for fundamental research in organic synthesis and chemical biology.

Basic Information

Product Name	Boc-6-Methyl-Dl-Tryptophan
CAS No.	446847-83-2
Molecular Formula	C₁₇H₂₂N₂O₄
Molecular Weight	318.37 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-6-methyl-DL-tryptophan; Boc-6-Me-DL-Trp-OH; (RS)-2-[(tert-Butoxycarbonyl)amino]-3-(6-methyl-1H-indol-3-yl)propanoic acid; 6-Methyl-DL-tryptophan N-Boc derivative; N-Boc-6-methyltryptophan; tert-Butyl (1-((RS)-2-carboxy-1-(6-methyl-1H-indol-3-yl)ethyl)carbamate; DL-6-Methyltryptophan, N-Boc protected; BOC-6-METHYL-DL-TRYPTOPHAN
EINECS	Contact for details

Quality Control

Our Boc-6-Methyl-Dl-Tryptophan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation, to ensure compliance with high-purity research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.