Description

4-Bromo-2-(1,1-Difluoroethyl)-1-Fluorobenzene is a high-value, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a difluoroethyl group, makes it a critical precursor for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly where fluorine substitution is desired to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Employed in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine and bromine atoms contribute to enhanced biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Materials: Used as a building block for fluorine-containing aromatic cores in electronic materials, contributing to improved charge transport, thermal stability, and optical properties.
• Cross-Coupling Reactions: The bromine substituent acts as an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form new carbon-carbon bonds.
• Fluorine Chemistry Research: A valuable substrate for studying nucleophilic aromatic substitution and other reactions involving polyfluorinated arenes in academic and industrial R&D settings.
• Specialty Polymer Monomer: Potential use in synthesizing specialty fluorinated polymers with unique chemical resistance, low surface energy, and specific dielectric properties.

Basic Information

Product Name	4-Bromo-2-(1,1-Difluoroethyl)-1-Fluorobenzene
CAS No.	445303-71-9
Molecular Formula	C8H6BrF3
Molecular Weight	239.04 g/mol
Synonyms	1-Bromo-4-(1,1-difluoroethyl)-2-fluorobenzene; 2-(1,1-Difluoroethyl)-4-bromo-1-fluorobenzene; 4-Bromo-2-(1,1-difluoroethyl)fluorobenzene; 1-Fluoro-4-bromo-2-(1,1-difluoroethyl)benzene; Benzene, 4-bromo-2-(1,1-difluoroethyl)-1-fluoro-; α,α-Difluoro-4-bromo-2-fluoroethylbenzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(1,1-Difluoroethyl)-1-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting purity, impurity profiles, and physical characteristics. Our quality commitment aligns with cGMP standards for advanced intermediates, ensuring reliable consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and potential concentration changes. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.