Description

1-Bromo-3-(1,1-Difluoro-Ethyl)-Benzene is a high-value, multi-functional aromatic building block characterized by its bromine and difluoroalkyl substituents, which impart unique reactivity and physicochemical properties. This compound is essential for facilitating advanced synthetic transformations, particularly in the development of complex molecular architectures where precise halogen and fluorine placement is critical. It serves as a key intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the synthesis of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring fluorinated aromatic motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoroethyl group can enhance biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic electronic materials, contributing to improved charge transport and thermal stability in displays and lighting.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl and conjugated systems.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for studying the effects of fluorine substitution on aromatic systems and exploring new fluorination methodologies.
• Polymer Modification: Incorporated as a monomer or modifier to introduce fluorine into polymer backbones, enhancing chemical resistance, lowering surface energy, and improving material performance.

Basic Information

Product Name	1-Bromo-3-(1,1-Difluoro-Ethyl)-Benzene
CAS No.	445303-70-8
Molecular Formula	C8H7BrF2
Molecular Weight	221.04 g/mol
Synonyms	3-(1,1-Difluoroethyl)-1-bromobenzene; 1-Bromo-3-(1,1-difluoroethyl)benzene; 3-Bromo-α,α-difluorotoluene; m-Bromo-α,α-difluorotoluene; (3-Bromophenyl)difluoromethyl; 1-Bromo-3-(difluoroethyl)benzene; Benzene, 1-bromo-3-(1,1-difluoroethyl)-
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(1,1-Difluoro-Ethyl)-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.