Description

3-Fluoro-4-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is a high-value organoboron building block, specifically a protected boronic acid derivative, essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for synthesizing novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing the 3-fluoro-4-(trifluoromethyl)phenyl moiety, particularly in drug discovery for CNS, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance biological activity, metabolic stability, and lipophilicity.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic units can tune electronic properties and improve device performance.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and catalysts used in asymmetric synthesis and other transition metal-catalyzed processes.
• Chemical Biology Probes: Useful for creating fluorinated probes and tags for studying biological systems and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis organizations (CSOs) and CDMOs producing tailored, high-value compounds for client projects.

Basic Information

Product Name	3-Fluoro-4-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester
CAS No.	445303-67-3
Molecular Formula	C13H15BF4O2
Molecular Weight	290.07 g/mol
Synonyms	[3-Fluoro-4-(trifluoromethyl)phenyl]boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane; 2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Fluoro-4-trifluoromethylbenzeneboronic acid pinacol ester; Pinacol [3-Fluoro-4-(trifluoromethyl)phenyl]boronate; Boronic acid, B-[3-fluoro-4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester (9CI); 3-Fluoro-4-(trifluoromethyl)phenylboronic acid, pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for every shipment. We support compliance with REACH, TSCA, and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). The product is light-sensitive (store away from light). Keep container tightly sealed under an inert atmosphere (argon/nitrogen) for long-term storage to maximize shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.