Description

2-(3-(Difluoromethyl)-4-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced pharmaceutical intermediate and versatile building block in modern organic synthesis. This compound is valued for its critical role in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures essential for drug discovery and material science. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially those containing fluorinated biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that benefit from the stability and reactivity of the boronate ester group.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is required.
• Cross-Coupling Reactions: A reliable reagent for palladium-catalyzed Suzuki-Miyaura couplings, facilitating carbon-carbon bond formation under mild conditions.
• Fluorine Chemistry: Serves as a specialized synthon for introducing difluoromethyl and fluoro-substituted aromatic systems into target molecules.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom synthesis manufacturers for client-directed projects.

Basic Information

Product Name	2-(3-(Difluoromethyl)-4-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	445303-65-1
Molecular Formula	C13H16B1F3O2
Molecular Weight	272.08 g/mol
Synonyms	(3-(Difluoromethyl)-4-fluorophenyl)boronic acid pinacol ester; 4-Fluoro-3-(difluoromethyl)phenylboronic acid pinacol ester; 2-[3-(Difluoromethyl)-4-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-(Difluoromethyl)-4-fluorobenzeneboronic acid pinacol ester; Pinacol [3-(difluoromethyl)-4-fluorophenyl]boronate; 4-Fluoro-3-difluoromethylbenzeneboronic acid pinacol ester; CAS 445303-65-1
EINECS	Contact for details

Quality Control

Every batch of our 2-(3-(Difluoromethyl)-4-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.