Description

4-Fluoro-3-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures in modern organic synthesis. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries, facilitating the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl and fluoro substituents enhance biological activity and stability.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers via palladium-catalyzed coupling reactions.
• Chemical Synthesis & Process Development: A versatile reagent for constructing complex molecular architectures in medicinal chemistry and process R&D laboratories.
• Catalyst & Ligand Development: Serves as a precursor for synthesizing specialized ligands and catalysts used in asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	4-Fluoro-3-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester
CAS No.	445303-14-0
Molecular Formula	C₁₃H₁₅BF₄O₂
Molecular Weight	290.06 g/mol
Synonyms	4-Fluoro-3-(trifluoromethyl)benzeneboronic acid pinacol ester; [4-Fluoro-3-(trifluoromethyl)phenyl]boronic acid pinacol ester; 2-[4-Fluoro-3-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Fluoro-α,α,α-trifluoro-m-tolylboronic acid pinacol ester; (4-Fluoro-3-trifluoromethylphenyl)boronic acid pinacol ester; Pinacol 4-Fluoro-3-(trifluoromethyl)phenylboronate
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent hydrolysis and maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.