Description

2-Chloro-5-Fluorobenzeneboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound is a critical intermediate in the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for forming carbon-carbon bonds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries to synthesize complex molecules and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific halogenated aromatic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for methodology development and the construction of complex molecular libraries.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	2-Chloro-5-Fluorobenzeneboronic Acid
CAS No.	444666-39-1
Molecular Formula	C6H5BClFO2
Molecular Weight	173.37 g/mol
Synonyms	(2-Chloro-5-fluorophenyl)boronic acid; 2-Chloro-5-fluorophenylboronic acid; 5-Fluoro-2-chlorobenzeneboronic acid; Boronic acid, B-(2-chloro-5-fluorophenyl)-; 2-Chloro-5-fluorobenzeneboronic acid pinacol ester (common derivative); 2-Cl-5-F-C6H3B(OH)2; 444666-39-1 (CAS); 2-Chloro-5-fluoro phenyl boronic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluorobenzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.