Description

2,2,2-Trifluoro-n-Piperidin-4-Ylmethyl-Acetamide is a high-purity trifluoroacetamide derivative featuring a piperidine scaffold, serving as a critical building block in advanced organic synthesis. This compound is valued for its unique structural properties that enable the introduction of both fluorine and a basic nitrogen-containing heterocycle into target molecules. It is primarily required by pharmaceutical and agrochemical research and development organizations for the synthesis of novel active ingredients, including potential drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl and piperidine groups can enhance biological activity and environmental stability.
• Chemical Biology Probe Development: Employed as a scaffold or labeling reagent in the design of molecular probes for studying enzyme function and protein-ligand interactions.
• Material Science Research: Acts as a precursor for specialty polymers and advanced materials where fluorine incorporation is desired for altering surface properties or stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2,2,2-Trifluoro-n-Piperidin-4-Ylmethyl-Acetamide
CAS No.	444617-44-1
Molecular Formula	C9H15F3N2O
Molecular Weight	224.23 g/mol
Synonyms	4-[(2,2,2-Trifluoroacetamido)methyl]piperidine; N-[(4-Piperidinyl)methyl]-2,2,2-trifluoroacetamide; 2,2,2-Trifluoro-N-(piperidin-4-ylmethyl)acetamide; 2,2,2-Trifluoroacetamide, N-[(4-piperidinyl)methyl]-; 444617-44-1; Trifluoroacetamide piperidine derivative; TFAPA intermediate
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-Piperidin-4-Ylmethyl-Acetamide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if necessary. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.