Description

4-Amino-3',5'-Bis(trifluoromethyl)biphenyl is a high-value, multi-functional biphenyl derivative characterized by its amino group and trifluoromethyl substituents. This compound is a critical advanced intermediate in modern organic synthesis, prized for its ability to impart unique electronic and steric properties to target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of drug candidates, particularly in the development of kinase inhibitors, receptor modulators, and other small-molecule therapeutics where the trifluoromethyl group enhances metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its structural motif can contribute to improved efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial R&D labs as a versatile scaffold for exploring new chemical reactions and creating libraries of compounds for high-throughput screening.
• Ligand Synthesis: Useful for preparing specialized ligands in catalysis, particularly for transition metal complexes used in cross-coupling and other transformative reactions.

Basic Information

Item	Details
Product Name	4-Amino-3',5'-Bis(trifluoromethyl)biphenyl
CAS No.	444143-45-7
Molecular Formula	C15H9F6N
Molecular Weight	317.23 g/mol
Synonyms	3',5'-Bis(trifluoromethyl)-[1,1'-biphenyl]-4-amine; 4-Amino-3',5'-bis(trifluoromethyl)-1,1'-biphenyl; 4-Amino-3,5-bis(trifluoromethyl)biphenyl; [1,1'-Biphenyl]-4-amine, 3',5'-bis(trifluoromethyl)-; 3',5'-Bis(trifluoromethyl)biphenyl-4-ylamine
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-3',5'-Bis(trifluoromethyl)biphenyl is manufactured under strict quality management protocols. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.