Description

(R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-Bis(Di(3,5-Xylyl)Phosphino)-3,3'-Bipyridine is a sophisticated, chiral bisphosphine ligand designed for high-performance asymmetric catalysis. This compound matters because it enables the precise control of stereochemistry in critical bond-forming reactions, leading to the production of enantiomerically pure intermediates and active pharmaceutical ingredients (APIs). It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require high selectivity and yield in asymmetric hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation Catalyst Ligand: A key component for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Synthesis: Used in the production of chiral drug candidates and complex molecules requiring high optical purity.
• Fine Chemical Manufacturing: Facilitates the creation of specialty chemicals, flavors, and fragrances with specific stereochemical configurations.
• Agrochemical Research: Applied in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis studies.
• Transition Metal Complexation: Serves as a chelating ligand for rhodium, iridium, and ruthenium to form active catalytic complexes.

Basic Information

Product Name	(R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-Bis(Di(3,5-Xylyl)Phosphino)-3,3'-Bipyridine
CAS No.	443347-10-2
Molecular Formula	C58H58N2O4P2
Molecular Weight	909.03 g/mol
Synonyms	(R)-DTMB-BIPHEP; (R)-2,2',6,6'-Tetramethoxy-4,4'-bis(di-3,5-xylylphosphino)-3,3'-bipyridine; (R)-DTMB-BIPHEP Ligand; (R)-(+)-DTMB-BIPHEP; (R)-DTMB-BIPHEP; (R)-DTMB-Biphep; (R)-DTMB-BIPHEP; (R)-DTMB-BIPHEP
EINECS	Contact for details

Quality Control

Our (R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-Bis(Di(3,5-Xylyl)Phosphino)-3,3'-Bipyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and NMR for structural confirmation, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and moisture-sensitive; the storage area should be cool, dry, and well-ventilated. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.