Description

(R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-Bis(Di(3,5-Xylyl)Phosphino)-3,3'-Bipyridine is a highly specialized, chiral bisphosphine ligand designed for asymmetric catalysis. This compound matters because it provides exceptional enantioselectivity and catalytic efficiency in the synthesis of complex chiral molecules, which are critical for advanced pharmaceutical and fine chemical production. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who are developing novel synthetic routes requiring precise stereochemical control.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Employed in palladium-catalyzed asymmetric cross-coupling reactions to form carbon-carbon and carbon-heteroatom bonds with high stereoselectivity.
• Asymmetric Allylic Substitution: Facilitates the creation of chiral centers via allylic alkylation and amination reactions.
• Pharmaceutical Process Chemistry: Used in the research, development, and scale-up of active pharmaceutical ingredients (APIs) requiring single enantiomer purity.
• Agrochemical Synthesis: Applied in the production of chiral herbicides, fungicides, and pesticides for enhanced efficacy and environmental profile.
• Academic & Industrial R&D: A valuable tool for methodological development in asymmetric synthesis and catalysis research.

Basic Information

Product Name	(R)-(+)-2,2',6,6'-Tetramethoxy-4,4'-Bis(Di(3,5-Xylyl)Phosphino)-3,3'-Bipyridine
CAS No.	442905-33-1
Molecular Formula	C58H58N2O4P2
Molecular Weight	909.03 g/mol
Synonyms	(R)-DTBM-SEGPHOS; (R)-DTBM-SegPhos; (R)-(+)-DTBM-SegPhos; (R)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (R)-2,2'-Dimethyl-4,4',6,6'-tetra(3,5-di-tert-butyl-4-methoxyphenyl)-4,4'-biphosphinine; (R)-DTBM-Segphos Ligand; (R)-3,3',5,5'-Tetra-tert-butyl-2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-1,1'-biphenyl (common misnomer); Chiral DTBM-SEGPHOS ligand
EINECS	Contact for details

Quality Control

Our (R)-(+)-DTBM-SEGPHOS is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including chiral purity verification by HPLC and 31P NMR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and specific performance metrics are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.