Description

(S)-4,4'-Bis(Di-3,5-Xylylphosphinoyl)-2,2',6,6'-Tetramethoxy-3,3'-Bipyridine is a sophisticated, chiral bisphosphine oxide ligand designed for high-performance asymmetric catalysis. This compound matters because it provides exceptional stereocontrol and stability in demanding synthetic transformations, enabling the production of enantiomerically pure intermediates critical for advanced materials and pharmaceuticals. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-purity ligands for complex metal-catalyzed reactions.

Application

• Asymmetric Hydrogenation: A key chiral ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Asymmetric C-C Bond Formation: Employed in cross-coupling, allylic alkylation, and other C-C bond-forming reactions to construct chiral centers with high fidelity.
• Catalyst Precursor Synthesis: Used to prepare well-defined transition metal complexes (e.g., with Rh, Ru, Ir) for homogeneous catalysis.
• Process Chemistry Development: Enables scalable, cost-effective routes to single-enantiomer active pharmaceutical ingredients (APIs) and agrochemicals.
• Academic & Industrial Research: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways in organic synthesis.
• Material Science: Potential applications in the synthesis of chiral polymers or frameworks with specific optical properties.

Basic Information

Product Name	(S)-4,4'-Bis(Di-3,5-Xylylphosphinoyl)-2,2',6,6'-Tetramethoxy-3,3'-Bipyridine
CAS No.	442905-31-9
Molecular Formula	C52H52N2O6P2
Molecular Weight	862.92 g/mol
Synonyms	(S)-DTBM-BIPYPO; (S)-DTBM-BIPYPO Ligand; (S)-4,4'-Bis(di(3,5-dimethylphenyl)phosphinoyl)-2,2',6,6'-tetramethoxy-3,3'-bipyridine; (S)-DTBM-BIPYPOX; (S)-DTBM-BIPY Phosphine Oxide; (S)-Bisphosphine Oxide Ligand; (S)-BIPYPO Derivative; Chiral Bipyridine Bisphosphine Oxide
EINECS	Contact for details

Quality Control

Every batch of our (S)-4,4'-Bis(Di-3,5-Xylylphosphinoyl)-2,2',6,6'-Tetramethoxy-3,3'-Bipyridine is produced and tested under strict quality management systems. We ensure high chiral purity and chemical integrity through advanced analytical techniques including HPLC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain optimal performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.