Description

(R)-4,4'-Bis(Di-3,5-Xylylphosphinoyl)-2,2',6,6'-Tetramethoxy-3,3'-Bipyridine is a sophisticated, chiral bisphosphine oxide ligand designed for high-performance asymmetric catalysis. This compound matters because it provides exceptional stereocontrol and stability in demanding transition-metal-catalyzed reactions, enabling the synthesis of complex chiral molecules with high enantiomeric purity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating advanced intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A key chiral ligand for the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Facilitates asymmetric C-C and C-X bond-forming reactions for high-value specialty chemicals.
• Catalyst Development & Screening: Serves as a privileged ligand scaffold in the discovery and optimization of new catalytic systems.
• Academic & Industrial Research: A valuable tool for methodological studies in organic synthesis and catalysis.

Basic Information

Product Name	(R)-4,4'-Bis(Di-3,5-Xylylphosphinoyl)-2,2',6,6'-Tetramethoxy-3,3'-Bipyridine
CAS No.	442905-30-8
Molecular Formula	C54H56N2O6P2
Molecular Weight	891.00 g/mol
Synonyms	(R)-DTBM-BIPY-Bisphosphine Dioxide; (R)-DTBM-BIPY-BisPO; (R)-4,4'-Bis(di(3,5-dimethylphenyl)phosphinyl)-2,2',6,6'-tetramethoxy-3,3'-bipyridine; (R)-DTBM-SEGPHOS Dioxide; (R)-DTBM-BIPY-PO; Chiral DTBM-BIPY Bisphosphine Oxide Ligand; (R)-Bis(di-3,5-xylylphosphinoyl)tetramethoxybipyridine
EINECS	Contact for details

Quality Control

Our production of (R)-4,4'-Bis(Di-3,5-Xylylphosphinoyl)-2,2',6,6'-Tetramethoxy-3,3'-Bipyridine adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, assay, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.