Description

3'-Chloro-4'-Trifluoromethyl-Biphenyl-2-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its biphenyl core substituted with chloro, trifluoromethyl, and nitrile functional groups. This compound is of significant commercial importance due to its role as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific molecular architectures. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the stability imparted by the trifluoromethyl group.
• Material Science Research: Serves as a monomer or building block for developing specialty polymers and liquid crystals with unique electronic properties.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions and as a ligand precursor in catalytic systems due to its biphenyl scaffold.
• Chemical Reference Standard: Used in analytical laboratories for method development, calibration, and quality control testing of related substances.

Basic Information

Product Name	3'-Chloro-4'-Trifluoromethyl-Biphenyl-2-Carbonitrile
CAS No.	442670-46-4
Molecular Formula	C14H7ClF3N
Molecular Weight	281.66 g/mol
Synonyms	2-Cyano-3'-chloro-4'-(trifluoromethyl)biphenyl; [1,1'-Biphenyl]-2-carbonitrile, 3'-chloro-4'-(trifluoromethyl)-; 3-Chloro-4-trifluoromethylbiphenyl-2-carbonitrile; 3'-Chloro-4'-trifluoromethyl-2-cyanobiphenyl; 2-(3-Chloro-4-(trifluoromethyl)phenyl)benzonitrile
EINECS	Contact for details

Quality Control

Our 3'-Chloro-4'-Trifluoromethyl-Biphenyl-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent composition suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.