Description

2-(2,4-Difluorophenyl)-4-Dimethylaminopyridine is a high-value, specialized organic compound that serves as a critical building block and catalyst in advanced chemical synthesis. Its unique structure, featuring both a dimethylaminopyridine (DMAP) moiety and a difluorophenyl group, makes it an essential reagent for facilitating challenging reactions, particularly in the synthesis of complex pharmaceutical intermediates and agrochemicals. This product is primarily targeted at R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity, reliable intermediates for their synthetic workflows.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for the development of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic systems.
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the difluorophenyl group imparts desirable biological activity and metabolic stability.
• Organocatalysis: Acts as a potent nucleophilic catalyst in acylation, alkylation, and other esterification reactions, often superior to standard DMAP due to enhanced electron-donating properties.
• Material Science Research: Employed in the synthesis of novel organic electronic materials, ligands for metal complexes, and specialty polymers.
• Cross-Coupling Reactions: Serves as a precursor or ligand in palladium-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig aminations.
• Fluorine Chemistry: A valuable scaffold for introducing fluorine atoms into target molecules, a common strategy in modern drug design to improve potency and pharmacokinetics.

Basic Information

Product Name	2-(2,4-Difluorophenyl)-4-Dimethylaminopyridine
CAS No.	441072-26-0
Molecular Formula	C13H12F2N2
Molecular Weight	234.25 g/mol
Synonyms	4-(Dimethylamino)-2-(2,4-difluorophenyl)pyridine; 2-(2,4-Difluorophenyl)-4-(dimethylamino)pyridine; 4-Dimethylamino-2-(2,4-difluorophenyl)pyridine; N,N-Dimethyl-4-[2-(2,4-difluorophenyl)pyridin-4-yl]amine; DFPA-DMAP; Difluorophenyl DMAP; 2,4-DFP-DMAP
EINECS	Contact for details

Quality Control

Every batch of 2-(2,4-Difluorophenyl)-4-Dimethylaminopyridine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, impurity profile, and residual solvents. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.