Description

Acetonitrile, [(1R,4S)-1,3,3-Trimethylbicyclo[2.2.1]Hept-2-Ylidene]-, (2E)- (9Ci) is a specialized chiral building block featuring a rigid norbornane-derived framework. This compound is valued for its unique stereochemistry and structural complexity, which are critical for imparting specific three-dimensional properties in advanced molecular synthesis. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the creation of advanced, stereospecific pesticides and herbicides where the specific spatial orientation of the molecule is crucial for bioactivity.
• Asymmetric Catalysis Ligand Precursor: Acts as a starting material for the synthesis of novel, sterically demanding ligands used in transition metal catalysis.
• Material Science Research: Employed in academic and industrial R&D for constructing complex organic frameworks and molecular machines due to its rigid, bicyclic structure.
• Fine Chemical Production: Utilized in the multi-step synthesis of high-value, low-volume specialty chemicals where precise stereocontrol is required.

Basic Information

Product Name	Acetonitrile, [(1R,4S)-1,3,3-Trimethylbicyclo[2.2.1]Hept-2-Ylidene]-, (2E)- (9Ci)
CAS No.	439689-20-0
Molecular Formula	C₁₂H₁₇N
Molecular Weight	175.27 g/mol
Synonyms	(2E)-[(1R,4S)-1,3,3-Trimethylbicyclo[2.2.1]hept-2-ylidene]acetonitrile; (1R,4S)-1,3,3-Trimethyl-2-(cyanomethylene)bicyclo[2.2.1]heptane; (E)-[(1R,4S)-1,3,3-Trimethyl-2-norbornylidene]acetonitrile; 2-[(1R,4S)-1,3,3-Trimethylbicyclo[2.2.1]hept-2-ylidene]acetonitrile; (E)-2-((1R,4S)-1,3,3-Trimethylbicyclo[2.2.1]heptan-2-ylidene)acetonitrile; Chiral Norbornylidene Acetonitrile Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity for sensitive synthetic applications. Certificates of Analysis (COA) are provided with each shipment, detailing critical parameters such as chiral purity, chemical purity, and impurity profiles. We employ HPLC, GC, and chiral analysis techniques to verify specifications, supporting compliance with cGMP standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.