Description

2-Fluoro-4-(Trifluoromethyl)-Dl-Phenylalanine is a fluorinated derivative of the amino acid phenylalanine, distinguished by its trifluoromethyl and fluorine substituents. This unique structure imparts significant metabolic stability and lipophilicity, making it a valuable non-natural amino acid building block for advanced research and development. It is primarily utilized by pharmaceutical and agrochemical R&D teams, as well as by manufacturers of specialty peptides and fine chemicals. The compound's properties are critical for modulating the biological activity and physicochemical characteristics of novel compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the fluorine and trifluoromethyl groups enhance bioavailability and environmental stability.
• Peptide Modification: Incorporated into synthetic peptides to improve their metabolic resistance, membrane permeability, and binding affinity.
• Chemical Biology Probe: Serves as a building block for creating labeled compounds and molecular probes to study biological pathways and enzyme mechanisms.
• Material Science: Potential monomer or additive in the synthesis of specialized polymers with unique surface properties or stability.
• Ligand Development: Used in medicinal chemistry for the structure-activity relationship (SAR) optimization of drug candidates.

Basic Information

Product Name	2-Fluoro-4-(Trifluoromethyl)-Dl-Phenylalanine
CAS No.	439587-15-2
Molecular Formula	C₁₀H₉F₄NO₂
Molecular Weight	251.18 g/mol
Synonyms	DL-2-Fluoro-4-(trifluoromethyl)phenylalanine; (±)-2-Fluoro-4-(trifluoromethyl)phenylalanine; 4-(Trifluoromethyl)-2-fluorophenylalanine; 2-Fluoro-4-trifluoromethyl-DL-phenylalanine; F-Phe(4-CF3)-OH; (RS)-2-Amino-3-[2-fluoro-4-(trifluoromethyl)phenyl]propanoic acid; α-Amino-2-fluoro-4-(trifluoromethyl)benzenepropanoic acid
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(Trifluoromethyl)-Dl-Phenylalanine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.