Description

1-[(3-Chloro-4-Fluorophenyl)Sulfonyl]Proline is a specialized proline derivative featuring a chlorinated and fluorinated phenylsulfonyl moiety, making it a valuable building block in advanced organic synthesis. This compound is engineered to serve as a key intermediate for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily targeted at research and development teams within the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate complex, functionalized heterocyclic structures into their molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of protease inhibitors, enzyme modulators, and other bioactive molecules targeting various disease pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its unique halogenated sulfonyl structure.
• Peptidomimetics & Drug Design: Serves as a constrained proline analog for creating peptide-like compounds with enhanced metabolic stability and binding affinity.
• Chemical Biology Probes: Employed in the design of molecular probes and inhibitors for studying enzyme function and cellular processes.
• Material Science Research: Potential intermediate for synthesizing functional polymers or ligands for catalysis.

Basic Information

Product Name	1-[(3-Chloro-4-Fluorophenyl)Sulfonyl]Proline
CAS No.	439093-24-0
Molecular Formula	C11H11ClFNO4S
Molecular Weight	307.72 g/mol
Synonyms	L-Proline, 1-[(3-chloro-4-fluorophenyl)sulfonyl]-; 1-(3-Chloro-4-fluorobenzenesulfonyl)pyrrolidine-2-carboxylic acid; (2S)-1-(3-Chloro-4-fluorophenyl)sulfonylpyrrolidine-2-carboxylic acid; 1-(3-Chloro-4-fluoro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid; 1-[(3-Chloro-4-fluorophenyl)sulfonyl]-L-proline; CAS 439093-24-0
EINECS	Contact for details

Quality Control

Our 1-[(3-Chloro-4-Fluorophenyl)Sulfonyl]Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from techniques such as HPLC, NMR, and MS. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.