Description

(R)-tert-Butyl 2-(2-(Benzyloxycarbonylamino)-2-Phenylacetamido)Acetate is a high-purity, chiral protected amino acid derivative essential for advanced pharmaceutical synthesis. This compound serves as a critical building block for the development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex molecules where stereochemical integrity is paramount. The product, identified by CAS number 439088-73-0, is supplied under stringent quality control to ensure batch-to-batch consistency for demanding applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide drugs and protease inhibitors.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring specific (R)-configuration.
• Peptide Chemistry: Serves as a protected amino acid derivative for solid-phase and solution-phase peptide synthesis (SPPS).
• Asymmetric Synthesis: Employed in medicinal chemistry for constructing chiral centers in drug candidate molecules.
• Bioconjugation: Potential use in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Research: A valuable tool compound for studying enzyme-substrate interactions and designing enzyme inhibitors.

Basic Information

Product Name	(R)-tert-Butyl 2-(2-(Benzyloxycarbonylamino)-2-Phenylacetamido)Acetate
CAS No.	439088-73-0
Molecular Formula	C22H26N2O5
Molecular Weight	398.45 g/mol
Synonyms	(R)-N-[(Benzyloxy)carbonyl]-α-phenylglycylglycine tert-Butyl Ester; Z-D-Phg-Gly-OtBu; tert-Butyl N-[(benzyloxy)carbonyl]-D-phenylalanylglycinate; (2R)-2-[[2-[(Phenylmethoxy)carbonylamino]-2-phenylacetyl]amino]acetic acid 1,1-dimethylethyl ester; Boc-D-Phenylalanylglycine tert-Butyl Ester (common misnomer); Z-D-Phenylglycylglycine t-Butyl Ester; 439088-73-0
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 2-(2-(Benzyloxycarbonylamino)-2-Phenylacetamido)Acetate is manufactured under controlled conditions to meet the exacting standards of pharmaceutical R&D. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. Our quality system is designed to support regulatory filings and ensure reliable, consistent performance in your synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.