Description

Cefazolin CAS NO 438540-91-1 is a first-generation cephalosporin antibiotic belonging to the β-lactam class, valued for its potent bactericidal activity against a broad spectrum of Gram-positive and some Gram-negative bacteria. Its primary commercial value lies in its critical role as a bulk pharmaceutical active ingredient (API) for the formulation of sterile injectable drugs, ensuring reliable and effective treatment. This product is essential for pharmaceutical manufacturers, research institutions, and compounding facilities involved in producing parenteral medications for surgical prophylaxis and serious infections.

Application

• Primary use as a bulk pharmaceutical active ingredient (API) in the manufacture of sterile injectable formulations.
• Formulation of powder for injection (PFI) and other parenteral dosage forms for clinical use.
• Key component in surgical prophylaxis medications to prevent post-operative infections.
• Treatment of serious infections caused by susceptible organisms, including skin and soft tissue infections, urinary tract infections, and respiratory tract infections.
• Used in veterinary pharmaceuticals for analogous therapeutic applications in animals.
• Reference standard and raw material in pharmaceutical research & development (R&D) and analytical laboratories.
• Starting material for the synthesis of more complex antibiotic derivatives in advanced research settings.

Basic Information

Product Name	Cefazolin
CAS No.	438540-91-1
Molecular Formula	C14H14N8O4S3
Molecular Weight	454.51 g/mol
Synonyms	Cefazolin Sodium; Cephazolin; Ancef; Kefzol; Zolicef; Cefamezin; 3-[[(5-Methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-, (6R,7R)-
EINECS	Contact for details

Quality Control

Our Cefazolin is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling, with specifications aligned to major pharmacopoeial standards such as USP, EP, and BP. A detailed Certificate of Analysis (COA) documenting purity, related substances, residual solvents, and microbiological data is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 6.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
pH (1% solution)	4.0 - 6.0
Specific Optical Rotation	-15° to -24°
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 0.17 EU/mg (for injectable grade)
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.