Description

L-Allothreonine,4,4-Difluoro-(9Ci) is a fluorinated derivative of the amino acid threonine, characterized by the introduction of two fluorine atoms at the 4-position. This specific modification is of significant interest for its potential to alter the metabolic stability, binding affinity, and physicochemical properties of bioactive molecules. It serves as a high-value building block in advanced organic synthesis, particularly for pharmaceutical research and development. Target industries include medicinal chemistry, agrochemical research, and specialized fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluorine substitution on peptide and protein interactions.
• Agrochemical Synthesis: Employed as a precursor in the design of advanced, fluorinated pesticides and herbicides with enhanced efficacy and environmental profiles.
• Biochemical Probe Development: Utilized in the creation of labeled compounds and probes for studying biological pathways and enzyme mechanisms.
• Peptidomimetics: Incorporated into synthetic peptide analogs to improve metabolic stability and membrane permeability for therapeutic applications.
• Fine Chemical Synthesis: Serves as a specialized reagent for the asymmetric synthesis of complex, fluorinated organic molecules in R&D settings.

Basic Information

Product Name	L-Allothreonine,4,4-Difluoro-(9Ci)
CAS No.	438477-05-5
Molecular Formula	C4H7F2NO3
Molecular Weight	155.10 g/mol
Synonyms	(2S,3R)-2-Amino-3,3-difluorobutanoic Acid; L-3,3-Difluoroallothreonine; 4,4-Difluoro-L-allothreonine; (2S,3R)-3,3-Difluoro-2-aminobutanoic Acid; L-α-Amino-β,β-difluorobutyric Acid (allothreo isomer); (2S,3R)-2-Azaniumyl-3,3-difluorobutanoate
EINECS	Contact for details

Quality Control

Our L-Allothreonine,4,4-Difluoro-(9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and specific analytical data is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.