Description

(S)-4-Hydroxy 4’-Methoxy Propranolol is a high-purity chiral intermediate and metabolite of the β-blocker propranolol. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, stereoselective synthesis, and as a reference standard. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in pharmacokinetic and bioanalytical studies.
• Metabolite Research: Serves as a key metabolite for investigating the metabolic pathways, efficacy, and safety profile of propranolol and related β-adrenergic antagonists.
• Chiral Synthesis Building Block: Employed as a sophisticated intermediate in the stereoselective synthesis of novel β-blocker derivatives or other chiral pharmaceutical compounds.
• Biochemical Research: Utilized in in-vitro studies to understand drug-receptor interactions and the stereospecific effects of β-blockade.
• Quality Control: Acts as an impurity standard to monitor and control the quality of propranolol API and related drug products during manufacturing.

Basic Information

Product Name	(S)-4-Hydroxy 4’-Methoxy Propranolol
CAS No.	437999-45-6
Molecular Formula	C₁₇H₂₁NO₄
Molecular Weight	303.35 g/mol
Synonyms	(S)-4'-Hydroxy-4-methoxypropranolol; (S)-4-Hydroxy-4'-methoxypropranolol; 1-[(1S)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-4-methoxy-9H-xanthen-9-one; (S)-4-Hydroxy-4'-methoxypropranolol; 4'-Hydroxy-4-methoxypropranolol (S-enantiomer); Propranolol metabolite 4'-OH-4-OCH3 (S-form); (S)-1-(Isopropylamino)-3-(4-methoxy-9-oxo-9H-xanthen-1-yloxy)propan-2-ol
EINECS	Contact for details

Quality Control

Our (S)-4-Hydroxy 4’-Methoxy Propranolol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.