Description

8-Chloro-2'-Deoxy-D-Guanosine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and intermediate for the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in nucleotide chemistry and the development of targeted molecular therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand DNA replication and repair mechanisms.
• Proteomics & Genomics: Employed in the development of probes and tools for studying nucleic acid interactions and modifications.
• Antiviral Agent Development: Investigated for its potential activity against various viral families by incorporating into viral DNA/RNA.
• Anticancer Drug Discovery: Serves as a building block for creating compounds designed to disrupt cancer cell proliferation.
• Diagnostic Reagent Synthesis: Used in the manufacture of labeled nucleotides for diagnostic assays and imaging.

Basic Information

Product Name	8-Chloro-2'-Deoxy-D-Guanosine
CAS No.	437715-62-3
Molecular Formula	C10H12ClN5O4
Molecular Weight	301.69 g/mol
Synonyms	8-Chloro-2'-deoxyguanosine; 8-Cl-dG; 2'-Deoxy-8-chloroguanosine; 8-Chloro-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; 8-Chloro-2'-deoxyguanosine; 8-Chloro-deoxyguanosine; Guanosine, 2'-deoxy-8-chloro-
EINECS	Contact for details

Quality Control

Our 8-Chloro-2'-Deoxy-D-Guanosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our processes are designed to meet the stringent requirements of pharmaceutical intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.