Description

[Abu]5-Cyclosporin CAS NO 437611-17-1 is a synthetic derivative of the well-known immunosuppressive cyclic peptide, Cyclosporin A. This modified compound is engineered for enhanced research utility, offering a valuable tool for studying structure-activity relationships and developing novel therapeutic agents. It is primarily targeted toward pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on immunology, drug discovery, and advanced medicinal chemistry.

Application

• Immunosuppressive Research: Serves as a key reference standard and active compound in studies investigating the mechanism of action of cyclosporin derivatives.
• Structure-Activity Relationship (SAR) Studies: Used to analyze how specific amino acid modifications impact biological activity and binding affinity.
• Drug Discovery & Development: Acts as a precursor or intermediate in the synthesis of novel immunosuppressive agents with potentially improved efficacy or safety profiles.
• Biochemical Assays: Employed in in vitro and cell-based assays to study calcineurin inhibition and T-cell activation pathways.
• Pharmaceutical Reference Standard: Used for quality control, method development, and validation in analytical laboratories (HPLC, LC-MS).
• Academic Research: Supports fundamental research in immunology and organic chemistry within university settings.

Basic Information

Product Name	[Abu]5-Cyclosporin
CAS No.	437611-17-1
Molecular Formula	C62H111N11O12
Molecular Weight	1202.6 g/mol
Synonyms	Cyclo[[(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl]-L-2-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]; [Abu]5-Cyclosporin A; [L-2-Aminobutyric acid]5-Cyclosporin A; Cyclosporin A, 5-(L-2-aminobutyrate); UNII-1W8M31T6UC
EINECS	Contact for details

Quality Control

Our [Abu]5-Cyclosporin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.