Description

Ethanone, 2-Fluoro-1-[(2S)-Tetrahydro-2-Furanyl]- (9Ci) is a high-value chiral fluorinated building block with significant utility in advanced organic synthesis. Its core value lies in the strategic incorporation of fluorine and a chiral tetrahydrofuran moiety, enabling precise control over molecular architecture and properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly where stereochemistry and fluorine substitution are critical for bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced, stereoselective pesticides and herbicides where the fluorinated structure enhances efficacy and environmental profile.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in the development of new catalytic methodologies for enantioselective synthesis.
• Material Science Precursor: Potential building block for specialty polymers and liquid crystals that require specific chiral and fluorinated motifs.
• Chemical Biology Probes: Utilized in the design of molecular probes to study enzyme mechanisms and biological pathways due to its fluorine atom (¹⁹F NMR active) and defined stereochemistry.

Basic Information

Product Name	Ethanone, 2-Fluoro-1-[(2S)-Tetrahydro-2-Furanyl]- (9Ci)
CAS No.	436801-06-8
Molecular Formula	C₆H₉FO₂
Molecular Weight	132.13 g/mol
Synonyms	2-Fluoro-1-[(2S)-Tetrahydro-2-Furanyl]Ethanone; (S)-2-Fluoro-1-(Tetrahydrofuran-2-yl)Ethanone; 1-(2S)-Oxolan-2-yl-2-fluoroethanone; (S)-1-(Tetrahydrofuran-2-yl)-2-fluoroethan-1-one; 2-Fluoro-1-(S)-Tetrahydro-2-FuranylEthanone; (S)-2-Fluoro-1-(2-Tetrahydrofuryl)Ethanone; Fluorinated Chiral Tetrahydrofuran Ketone; CAS 436801-06-8
EINECS	Contact for details

Quality Control

Our production of Ethanone, 2-Fluoro-1-[(2S)-Tetrahydro-2-Furanyl]- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including chiral HPLC, ¹H/¹⁹F/¹³C NMR, and GC-MS to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.